Interestingly, cause and effect relationships in cancer are difficult to prove e.g. whether shortened telomeres initiate or prevent cancer. Correlative evidence might appear to show that telomere uncapping and resultant DNA damage signals may suppress cancer cell cycle checkpoints, because the damage cannot be repaired in the absence of telomerase. However, when alterations in specific cell cycle regulatory pathways, e.g. inactivation of p53, cells can continue to divide still having critically shortened telomeres, while expressing DNA damage pathways. This is a bypass of senescence (M1) with cells continuing to divide. When many telomeres are shortened to the extent that end - end chromosome fusions occur, this produces chromosome - breakage - fusion - bridge cycles known as M2 or crisis. Crisis stage M2 leads to extensive chromosomal alterations, the hallmark of cancer. It is hypothesized that transpositional states based in quantum entropic conditions lead to transitions from altered cell cycle checkpoints encouraging cells to grow to meet increased energy exigencies. Terminally shortened telomeres may not prevent cell divisions in a rarity of human cells that can bypass this stage. This type of rare cell manifests the hallmarks of telomere stability with reactivation of telomerase. The fundamental mechanisms underpinning a bypass of senescence M1 and continuance to the crisis point (M2) may be based in quantum phenomena which ultimately determine such biochemical changes. Actively dividing cancer cells could then survive and continue to replicate. Further hypothesized is the idea that an electromagnetic physiologic immune response provides the encouragement for certain cells to divide and grow while avoiding crisis stages, in spite of having terminally shortened telomeres. This explanation is proposed for contrasting normal mitosis versus neoplasia.
It is further hypothesized that MRT may stimulate up regulation of telomerase when telomere length diminishes too greatly in specific tissues, and functionality is decreased. Telomerase is projected to be a defensive mechanism of the body, because telomerase increases telomere length. In cancer, when telomeres become too shortened, telomerase is up-regulated to increase telomere length, but in crisis stages, M1 -M2, quantum state entropy is too great for the defensive mechanism to overcome. Thus, telomerase produces increased lengths of telomeres in actively dividing cancer cells, therein keeping the cancer cells dividing and surviving; and as actively mitotic cells increase energies from fissions/ fusions of subatomic particles, the cancer cells increase energy, as the chain reaction proceeds. In simple terms, the cancer cells have superseded the normal cells while using the natural defense mechanisms of normal cells to survive and multiply. The degree of chaos/quantum entropy from fissions/fusions overcomes the natural defense mechanisms based in telomerase production.
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Dr. Jacobson paints with the passion of Van Gogh, the skill of Caravaggio, the division of Michelangelo and the creativity of Picasso. His life's work include more than 800 oil paintings, thousands of drawings, hundreds of water colors, pastels and numerous inks. His discovery is called perspectivism. Perspectivism is a new trend philosophical thought applied to a vision encompassing scientific iconography.
As a theoretical physicist he envisions string theory. His recent paintings reflect a vision of string theory, the hottest topic in modern physics. It speaks to the unification and communication between all things in the universe; large and small, near and distant. His dedication to oil painting was enhanced by his search for the unified field equation, earnestly trying to visually represent the infinite number of dimensions comprising the world we see and the world we don't see. He has exhibited his paintings throughout the world for nearly 50 years, having numerous one-man exhibitions in NYC both in galleries and museums. His paintings appear in numerous collections of celebrities. As a world class medical researcher, he has incorporated medical images in his paintings with meaningful philosophical import. Dr. Jacobson has published more than 100 scientific articles in peer reviewed journals and is the inventor of 50 patents both national and international. His discovery of the unified field equation that Einstein sought has been applied to medical therapeutics, and prospectively includes a vision of controlled thermonuclear fusion power. A pioneer in the field of biolelectromagnetics, he has lectured on the theory and practice of Jacobson Resonance throughout the world for more than 30 years. He has lectured 3 times for the Nobel Assembly in medicine and physiology in Stockholm, Sweden, the Russian Academy of Sciences in Moscow, the Indian Medical Association in Calcutta, and Monte Carlo at the behest of the Princess Antoinette de Monaco. He has directed basic science and clinical research throughout the world including the USA, Canada, Mexico, Spain, Sweden, Switzerland, Greece, Italy, India and the Bahamas just to name a few. Dr, Jacobson considers himself an artist, and a philosopher of truth. His creativity knows no subject boundaries as hr has written 25 books, hundreds of poems, songs, philosophical essays, novels and short stories. Truly a renaissance genius, this mans paintings of visual plasticity, geometrical balance, color harmony and imagery is second to non over the last century. Perspectivism: The Art of Life
Perspectivism is thought to represent a “world” point of view. One sees the interrelation of all facets of experience, creating an integrated picture of life. In this sense, an individual views the parts of his reality in terms of the depth of their meaning to him, with the whole of perception; including the mind, heart and soul. Perspectivism is a school of philosophy that contains no dogma. It is left to the individual to interpret what he sees, thinks and feels, in view of what he intuitively knows is right and good. The school of thought believes in the basic goodness and uniqueness of all people, regardless of past choices and outcomes. The individual’s freedom of choice, behavior and belief system, determines that world view, serving as guide for all future decisions; realizing that circumstances surrounding any given situation are different. How then can one know that all people have this integrity? Because, as Lao Tzu said, “It could all begin in me.” Upon realization that this view is most natural, easy and the source of happiness, human intuition yields the view that all people are compeer (equal) in the eyes of the universal design. The honest individual, who seeks peace in freedom, and love with justice, will protect the integrity of all members of his reality; because it is the same as protecting himself. Fear and guilt are denied their power to divide men. Judgment of self is paramount, while judgment of others is secondary, because it all begins and end with the individual. We are all part of the grand, universal design. Yet, humble in our awareness of limitation, relative to an infinite cosmos, we all know the connection of humanity. As all people are points of reference in the universe, we know humanity as a whole must serve a purpose. Otherwise, we could not appreciate consciousness. Lao Tzu’s words, “From wonder into wonder, Existence opens,” drives us all to comprehend need for realizing ideals of freedom, justice, peace, love and brotherhood- in ourselves. The final decision of each, by each, for all, is based in Lao Tzu’s view, “What is, is the was of what shall be.” |